malaria-678d0d2d18c3a

Malaria

The call selected 10 projects focusing on malaria prevention and control in Brazil.
desafio

Challenge

In 2018, 194.271 malaria cases were notified in Brazil. 99% of those cases occurred in the Amazon region. From January to March 2019, the country registered 31.872 cases, according to Ministry of Health data, representing a reduction of 38% in comparison with the same period of the previous year. Spite the progress, Brazil still accounts for 22% of all malaria cases in Latin America, lagging behind Venezuela, which accounts for 53% of cases, per the last world malaria report.

Frame 13

Goal

To support the development of scientific and/or technological research (about prevention, detection and fight against malaria in Brazil) that can effectively contribute to the advancement in knowledge, training of human resources, creation of products and improvement of health surveillance programs, control, elimination and prevention of this neglected disease, so as to achieve the Sustainable Development Goals, in line with elimination program established by the World Health Organization, with the purpose of improving the health conditions of the Brazilian population.

Projects were classified according to the following themes:

  • Treatment: Evaluation of adherence to malaria treatment in Brazil and compliance with the therapeutic regimens recommended by the Ministry of Health;
  • Diagnosis and Epidemiology: Strategies to improve surveillance of malaria cases in the Amazon, in order to better understand the outbreaks of infection and the impact of migration patterns through the development of new diagnostic methods and surveillance approaches;
  • Vector Biology and Control: To support studies that increase knowledge about the vector, including its biology, interaction with the plasmodium and relationship with the environment, with the purpose of preventing transmission;
  • Economic Impact Assessment of Social Technologies: To support the development of studies that provide an understanding of the economic impact of malaria in endemic (with transmission) and non-endemic (without transmission) areas of Brazil and the development of more accurate tools for this assessment.
Frame 13 (1)

Project

Phase I, single-center, randomized, open, parallel-group study for pharmacokinetic evaluation of artesunate-mefloquine use in combination with primaquine and tafenoquine (AMino Study)
Artesunate/mefloquine (ASMQ) has good efficacy, safety, and tolerability when used with primaquine (PQ) on the treatment of vivax malaria, falciparum …
Malaria
Insecticide resistance evaluation in anopheline from high malaria-endemic regions from Brazil
This project intends to determine the susceptibility profile to new and existing insecticides used in the public health in high malaria-endemic areas …
Malaria
Identification of metabolomic signatures associated to the hypnozoite activation in Plasmodium vivax (HIPNOPRINT)
This study seeks to search for molecular markers capable of predicting the activation of hypnozoites, unique and dormant forms of vivax malaria. To do…
Malaria
The economic cost of malaria in Brazil
This study will develop a broad methodology to estimate the economic cost of malaria in Brazil, separating by state and type of parasite. Studies that…
Malaria
Phase II study to evaluate primaquine safety and tolerability for radical cure of uncomplicated Plasmodium vivax malaria in children (CHILDPRIM Study)
This clinical trial seeks to fill a global gap in the treatment of uncomplicated vivax malaria: to evaluate the safety and tolerability of short and l…
Malaria
Data Science applied to epidemiological and demographic information as a strategy to simulation and malaria vigilance monitoring in the Brazilian Amazon
The objective of this project is to develop data visualization tools and malaria outbreaks spreading simulation-based in machine learning methods, usi…
Malaria
Frame 13 (2)

Published Studies

Frame 13 (3)

News

31/07/2023
Source:
portal.fiocruz.br

LAUNCH – GC PALOP RFP

08/08/2023
Source:
gcgh.grandchallenges.org

Six groundbreaking Brazilian projects were selected in the Grand Challenges RfP for “Catalyzing Equitable Artificial Intelligence (AI) Use.”

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